ISBN: 9783031300646
Код товара 155389
Targeting the DNA Damage Response for Cancer Therapy
ISBN: 9783031300646
Код товара 155389
18 167 ₽
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Если Вы закажете книгу до 17.01.2025, то мы привезём её ориентировочно 28.02.2025.
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Автор
Yap
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Издатель
Springer
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Тип обложки
Hardback
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Год издания
2023
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ISBN
9783031300646
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Язык
ENG
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Кол-во страниц
328
О чём книга?
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
Evolution of the development of PARP inhibitors.- Exploiting cancer synthetic lethality in cancer – Lessons learnt from PARP inhibitors.- Mechanisms of PARP inhibitor resistance.- Development of homologous recombination functional assays for targeting the
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