Neuraxial Therapeutics

2024

новинки

ISBN: 9783031395574
Код товара 154652

27 950 ₽

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Если Вы закажете книгу до 17.01.2025, то мы привезём её ориентировочно 28.02.2025.

Автор
Yaksh
Издатель
Springer
Тип обложки
Hardback
Год издания
2024
ISBN
9783031395574
Язык
ENG
Кол-во страниц
830

О чём книга?

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.

History and Evolution of Intrathecal Drug Delivery.- Intraspinal Anatomy: Considerations in Intrathecal Drug Delivery.- Spinal Target Receptors in Intrathecal Drug Delivery.- Mechanisms of Action of Intrathecally Administered Agents.- Physicochemical Prop

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