Chapter 1_Global trends in epidemiology of Coronavirus Disease 2019 (COVID-19). -Chapter 1.1. Introduction. -Chapter 1.2. 21^st century SARS-CoV-2 outbreaks, epidemics. -Chapter 1.3.Worldwide surveillance systems. -Chapter 1.4. Regions of potential threat. -Chapter 1.5. Pandemic SARS-CoV-2. -Chapter 1.6. Conclusions. -Chapter 1.7. Future Perspectives. -Chapter 1.8. References. -Chapter 2_Genome organization and Pathogenesis of novel Coronavirus 2019 (SARS-CoV-2). -Chapter 2.1. Introduction. -Chapter 2.2. Structure and genome of SARS-CoV-2. -Chapter 2.3. Replication and life cycle of virus. -Chapter 2.3.1 Attachment. -Chapter 2.3.2.Entry. -Chapter 2.3.3. Receptors. -Chapter 2.3.4. Uncoating. -Chapter 2.3.5. Synthesis of viral RNA. -Chapter 2.3.6. Viral proteins . -Chapter 2.3.7. Egress. -Chapter 2.4. Conclusions. -Chapter 2.5. Future Perspectives. -Chapter 3_Host immune response against human SARS-CoV-2 infection. -Chapter 3.1. Introduction. -Chapter 3.2. Immune response. -Chapter 3.3. Humoral immune response. -Chapter 3.4.Cellular immune response. -Chapter 3.5. Conclusions. -Chapter 3.6. Future Perspectives. -Chapter 4_Emergence and Re-emergence of SARS Coronaviruses. -Chapter 4.1. Introduction. -Chapter 4.2. SARS-CoV to SARS-CoV-2: RNA recombination, antigenic shift and antigenic drift. -Chapter 4.3. Conclusions. -Chapter 4.4. Future Perspectives. -Chapter 5_Transmission cycle of SARS-CoV and SARS-CoV-2. . -Chapter 5.1. Introduction. -Chapter 5.2. Coronavirus Transmission cycle. -Chapter 5.2.1. Transmission among animals. -Chapter 5.2.2. Transmission in animals to human. -Chapter 5.2.3.Transmission among humans. -Chapter 5.2.4. Other hosts. -Chapter 5.3. Conclusions. -Chapter 5.4. Future Perspectives. -Chapter 6_Preparing for the perpetual challenges of pandemics of Coronavirus infections with special focus on SARS-CoV-2. -Chapter 6.1. Introduction. -Chapter 6.2. Strategies for pandemic preparedness for Coronavirus. -Chapter 6.2.1. Updated Surveillance system. -Chapter 6.2.2. Strategies for implementation of laboratory diagnostic services during pandemics. -Chapter 6.2.3. Management of bulk vaccines, antiviral drugs. -Chapter 6.3. Promoting facilities for treatment and hospitalisation, healthcare personnel, maintenance of hygiene and disinfection during pandemics. -Chapter 6.3.1.Global management strategies of Coronavirus infection. -Chapter 6.3.2.Economic Consequences of pandemic risk. -Chapter 6.3.3.Conclusions. -Chapter 6.3.4. Future Perspectives. -Chapter 7. Clinical manifestations and diagnosis of human SARS-CoV-2 infection. . -Chapter 7.1. Introduction. -Chapter 7.2. General Symptoms of SARS-CoV-2 infection. -Chapter 7.3. Clinical Course. -Chapter 7.4. Clinical complications. -Chapter 7.5. Diagnosis of SARS-CoV-2. -Chapter 7.6. Conclusions. -Chapter 7.7. Future Perspectives. -Chapter 8. Treatment and Drugs for SARS-CoV-2. . -Chapter 8.1. Introduction. -Chapter 8.2. Antiviral drugs for SARS-CoV-2. -Chapter 8.3. Current available drugs, Pharmacokinetics, Toxicity, Efficacy, Resistance, Drug Interactions, Recommendations for Use. . -Chapter 8.4. Complementary and alternative medicines for SARS-CoV-2. . -Chapter 8.5. Conclusions. -Chapter 8.6. Future Perspectives. -Chapter 9. Prevention and control strategies for SARS-CoV-2 infection. . -Chapter 9.1. Introduction. -Chapter 9.2. SARS-CoV-2 vaccine development. -Chapter 9.3. Types of Coronavirus vaccines. -Chapter 9.4. Efficacy and effectiveness of Coronavirus vaccines. -Chapter 9.5. Control strategies of Coronavirus infection. -Chapter 9.6. Conclusions

Module 1_Global trends in epidemiology of Coronavirus Disease 2019 (COVID-19).- Module 2_ Genome organization and Pathogenesis of novel Coronavirus 2019 (SARS-CoV-2).- Module 3_Host immune response against human SARS-CoV-2 infection.- Module 4_ Emergence