ISBN: 9781071625712
Код товара 155021
Translational Research Methods in Neurodevelopmental Disorders
ISBN: 9781071625712
Код товара 155021
15 372 ₽
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Если Вы закажете книгу до 15.04.2024, то мы привезём её ориентировочно 05.06.2024.
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Автор
Martin
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Издатель
Springer
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Тип обложки
Soft cover
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Год издания
2023
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ISBN
9781071625712
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Язык
ENG
О чём книга?
This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods in Neurodevelopmental Disorders is a valuable resource for all researchers who want to learn more about this important and developing field.
Using Lentiviral shRNA Delivery to Knock-Down Proteins in Cultured Neurons and In Vivo.- Synaptosomal Preparation and Its Application in Preclinical Studies.- Assessing the Nanoscale Organization of Excitatory and Inhibitory Synapses using Recombinant Pro
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